![]() Survival analysis was performed and Kaplan–Meier curves were drawn for patients in different treatment groups. Binomial Logistic regression analysis was performed to identify independent risk factors for mortality. The primary outcome was 90-day mortality, and secondary outcomes included 28-day mortality, in-hospital mortality, length of hospital stay, and length of intensive care unit (ICU) stay. Patients were divided into hydrocortisone treatment groups and hydrocortisone plus fludrocortisone treatment groups. Methods: Baseline characteristics and treatment regimens of patients with septic shock treated with hydrocortisone from the Medical Information Mart for Intensive Care-IV database were collected. ![]() 5Precision Medicine Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, Chinaīackground: Several clinical trials of corticosteroids have been carried out in the treatment of septic shock, however, the therapeutic effect of the most widely used hydrocortisone is still controversial, and no studies have directly compared hydrocortisone versus hydrocortisone plus fludrocortisone for patients with septic shock.4School of Clinical Medicine, Chongqing Medical and Pharmaceutical College, Chongqing, China.3Department of Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.2Department of Orthopedic Surgery, Anyue Hospital of Traditional Chinese Medicine, Second Ziyang Hospital of Traditional Chinese Medicine, Ziyang, China.1Department of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ultrasound Molecular Imaging, Institute of Ultrasound Imaging, Chongqing, China.Xiaoxiao Cheng 1 †, Zhiqin Fu 2 †, Yiting Liu 3, Xiaoyu Zheng 4 and Tianyang Hu 5 *
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